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I am a tenure-track assistant professor of Biostatistics and Bioinformatics, and Human Genetics at Emory University. My research develops statistical methodologies to understand disease mechanisms using single-cell genomics and genetics data.
My primary focus is on gene networks, including how to infer them from single-cell multi-omics data, and how they mediate genetic effects on diseases. We also work on the genetic regulation of single-cell gene expression.
My lab collaborates closely with disease researchers, with current work in Alzheimer's disease, lung disease, and sickle cell disease. We always look forward to new collaborations and new scientific questions.
My work has been published in leading journals across statistics and the life sciences, including Journal of the American Statistical Association, Journal of the Royal Statistical Society, Nature Communications, and Science Translational Medicine. My research is supported by NIH funding and pilot grants at Emory University.
Prior to Emory, I received my Ph.D. training in Biostatistics at Yale School of Public Health in 2023, where I was fortunately co-advised by Dr. Hongyu Zhao and Dr. Zhou Fan.
Research interests
Statistical genomics and genetics:
Gene networks
Cell-type-specific analysis
Genetic regulation of gene expression
Statistical methodologies:
High-dimensional network estimation
Latent-variable model
Education
Ph.D. in Biostatistics, 2023
Yale University
B.S. in Statistics, 2018
Sun Yat-sen University
News
[July 2026] Dongsoo's abstract "TL-TWAS: Transfer Learning for TWAS Using Large-Scale Transcriptomic Resources in Underpowered Target Context" was accepted as a Platform Presentation at 2026 IGES Annual Meeting in Quebec, Canada. Great job, Dongsoo!
[May 2026] Chang served as the co-chair of the Local Organizing Committee for STATGEN 2026, the third annual conference of the American Statistical Association's Section on Statistics in Genomics and Genetics. Many thanks to all group members for volunteering and presenting!
[April 2026] Congratulations to Dongsoo Lee, the first-place recipient of the Patel-Naik Award! This award recognizes pre-candidacy PhD students in RSPH BIOS who develop outstanding and innovative research proposals.
[April 2026] scTWAS has been published in Nature Communications. In this work, we developed a powerful statistical method for performing cell-type-specific transcriptome-wide associations studies (TWAS) with single cell data. Big thanks to our wonderful collaborator Zhaotong Lin from Florida State University.
[March 2026] Both Dongsoo Lee and Yutong Liu's abstracts have been accepted as invited talks, and Angela Yu and Weiwei Wu will also present their invited posters at STATGEN 2026. Congratulations, Dongsoo, Yutong, Angela and Weiwei!
[March 2026] Chang received a new pilot award from Emory Goizueta ADRC, which proposes to study the impact of air pollution on aging brain using single-cell transcriptomics.
Email: chang.su@emory.edu
Office: GCR 334, 1534 Clifton Rd, Atlanta, GA 30322
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